Tab Application Banner
  • Users Online: 1031
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2010  |  Volume : 5  |  Issue : 1  |  Page : 11-15

Relating bone marrow oedema to hs-CRP in knee osteoarthritis


1 Department of Rheumatology, Al-Hussein University Hospital, Azhar University, Cairo, Egypt
2 Department of Clinical Pathology, Al-Hussein University Hospital, Azhar University, Cairo, Egypt
3 Department of Rheumatology, USC Keck School of Medicine, Los Angeles, CA

Correspondence Address:
H Bassiouni
Department of Rheumatology, Al-Hussein University Hospital, Azhar University, Cairo, Egypt

Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Objective: To study the correlation between bone marrow oedema (BME) on knee magnetic resonance imaging (MRI) and plasma high sensitive-CRP (hs-CRP) levels in patients with symptomatic osteoarthritis (OA) of the knee. Methods: Thirty patients with symptomatic OA of the knee were included and stratified into three equal groups con- sisting of normal alignment, varus or valgus misalignment of symptomatic knee. Radiographic scoring using Kellgren-Lawrence grading (K-L grade) was performed and an MRI of the knee taken. Intensity of pain was evalu- ated using a pain visual analogue scale (VAS) and the functional status determined by Lequesne functional index. In addition, hs-CRP was estimated in all patients and in 20 healthy controls. Results: BME was present in 14 patients (46%) with OA and in none of the controls. Patients with BME had signifi- cantly longer disease duration, a higher lequesne score, suggesting greater functional impairment and more advanced radiological changes. A significantly higher number of patients (12/30, 40%) had an elevated hs-CRP than healthy controls (2/20, 10%, P = 0.02). There was, however, no association between hs-CRP and BME. Patients with varus and valgus deformities harboured BME on the medial and lateral tibiofemoral compartments, respectively. Conclusion: BME is a feature of advanced OA of the knee and is associated with radiographic progression, a greater functional impairment and longer disease duration. It is, however, not associated with raised hs-CRP levels.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed290    
    Printed9    
    Emailed0    
    PDF Downloaded32    
    Comments [Add]    

Recommend this journal