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REVIEW ARTICLE
Year : 2011  |  Volume : 6  |  Issue : 1  |  Page : 13-25

Sjögren's syndrome: Infections that may play a role in pathogenesis, mimic the disease, or complicate the patient's course


Rheumatology Clinic, Scripps Memorial Hospital and Research Foundation, La Jolla, CA, USA

Correspondence Address:
Robert I Fox
Rheumatology Clinic, Scripps Memorial Hospital and Research Foundation, La Jolla, CA, USA

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Source of Support: None, Conflict of Interest: None


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Sjögren's syndrome (SS) is a systemic autoimmune disorder characterized by lymphocytic infiltration of the lacrimal and salivary glands, leading to dryness of the eyes and mouth. Epidemiologic studies have indicated a role of both genetic and environmental factors in pathogenesis. It is likely that viral infection can create an inflammatory micro- environment that alters the disposition of apoptic fragments that serve as autoantigens. Thus, the search for a single viral agent that is causative is likely to prove difficult. Attention has focused on viruses that have tropism for the sali- vary and lacrimal glands, particularly members of the herpesvirus family. Other infectious agents too may mimic the clinical appearance of SS or complicate the disease. This article reviews the role of infections in patients with Sjogren's syndrome.


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