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ORIGINAL ARTICLE
Year : 2011  |  Volume : 6  |  Issue : 4  |  Page : 168-172

Role of vascular endothelial growth factor and monocyte chemoattractant protein-1 in Behηet's disease


1 Lecturer, Department of Rheumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2 Assistant Professor, Department of Rheumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
3 Lecturer, Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
4 Lecturer, Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Correspondence Address:
Soha ElDessouki Ibrahim
Lecturer, Department of Rheumatology, Faculty of Medicine, Ain Shams University, Cairo
Egypt
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Source of Support: None, Conflict of Interest: None


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Objectives: To study the role of vascular endothelial growth factor (VEGF) and monocyte chemoattractant protein-1 (MCP-1) in Behηet's disease and their relation to clinical manifestations particularly vascular manifestations and disease activity. Methods: Forty Behηet's disease patients (32 males, 8 females), diagnosed according to the criteria proposed by the International Study Group for Behηet's disease were assessed clinically and serum VEGF and MCP-1 were measured by enzyme-linked immunosorbent assay. Results: Serum VEGF and MCP-1 levels were detected in patients and control groups with highly significant increase in Behηet's group. A highly significant increase in the level of serum VEGF and MCP-1 was found in patients with vascular manifestations compared to those without vascular complications. A significant increase in the level of VEGF and MCP-1 was found in patients with active disease compared to inactive. Conclusion: Our findings suggest that serum VEGF and MCP-1 levels are elevated in active Behηet's patients and in patients with vascular complications. So, we conclude that VEGF and MCP-1 play a crucial role in the pathogen- esis of vascular complications of Behηet's disease. Therefore, the serum levels of these cytokines serve to predict a possible acute thrombosis in Behηet's disease.


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