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REVIEW ARTICLE
Year : 2012  |  Volume : 7  |  Issue : 5  |  Page : 92-98

Henoch-Schonlein purpura: An update


Department of Paediatrics, Kasturba Medical College, Mangalore, Manipal University, Karnataka, India

Correspondence Address:
Nutan Kamath
Department of Paediatrics, Kasturba Medical College, Mangalore, Manipal University, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.1016/S0973-3698(12)60034-X

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Henoch-Schonlein purpura (HSP), the commonest childhood vasculitis, is characterised by non-thrombocytopaenic palpable purpura, arthritis or arthralgias, gastrointestinal and renal involvement. The peak incidence is between the ages of 4 years and 8 years with a male preponderance. Though the diagnosis is usually clinical, a tissue biopsy revealing leucocytoclastic vasculitis is helpful when the presentation is atypical. Renal involvement in the form of an immune complex glomerulonephritis is the most serious long-term complication. The aetiopathogenesis, classifica- tion, clinical features, relevant Indian data, and a stepwise management approach with corticosteroids and immuno- suppressive agents per the renal histology are discussed.


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