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Year : 2013  |  Volume : 8  |  Issue : 2  |  Page : 61-64

A cross-sectional study to assess the association of systemic lupus erythematsous disease activity with levels of high sensitivity C-reactive protein

1 Department of Medicine, Medical College, Kolkata, India
2 Department of Medicine, Rheumatology Division, Medical College, Kolkata, India
3 Department of Preventive and Social Medicine, All India Institute of Hygiene and Public Health, Kolkata, India

Correspondence Address:
Rathindra Nath Sarkar
Department of Medicine, Rheumatology Division, Medical College, Kolkata
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Source of Support: None, Conflict of Interest: None

DOI: 10.1016/j.injr.2013.03.003

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Background: Earlier studies have shown that active systemic lupus erythematosus (SLE), though an inflammation, is not associated with high C-reactive protein (CRP) levels. But a few recent studies have shown that high sensitivity CRP (hsCRP) may be elevated in SLE and is associated with organ damage. Objective: To evaluate the association between hsCRP levels and SLE disease activity index (SLEDAI). Methods: This cross-sectional study was conducted in 40 SLE patients. The SLEDAI was calculated and the hsCRP level was measured in the serum. Correlation between hsCRP levels and SLEDAI was assessed. Relationship of hsCRP levels with individual components of SLEDAI was also analyzed. Results: Out of 40 patients, 38 (95%) were female. The mean age was 28.15 years. The mean SLEDAI was 27.4 ± 17.8, indicating that most of the patients had high disease activity. The mean hsCRP levels were 6.64 ± 5.09 mg/L. hsCRP levels and SLEDAI showed strong positive correlation (Pearson's correlation coefficient r ¼ 0.91; p < 0.0001). hsCRP levels were higher in patients with serositis, nephritis, nervous system manifestations and immunological abnormalities. Conclusion: hsCRP levels reflect SLE disease activity and are higher in patients with major organ involvement.

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