Tab Application Banner
  • Users Online: 1311
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2013  |  Volume : 8  |  Issue : 2  |  Page : 61-64

A cross-sectional study to assess the association of systemic lupus erythematsous disease activity with levels of high sensitivity C-reactive protein


1 Department of Medicine, Medical College, Kolkata, India
2 Department of Medicine, Rheumatology Division, Medical College, Kolkata, India
3 Department of Preventive and Social Medicine, All India Institute of Hygiene and Public Health, Kolkata, India

Correspondence Address:
Rathindra Nath Sarkar
Department of Medicine, Rheumatology Division, Medical College, Kolkata
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.injr.2013.03.003

Rights and Permissions

Background: Earlier studies have shown that active systemic lupus erythematosus (SLE), though an inflammation, is not associated with high C-reactive protein (CRP) levels. But a few recent studies have shown that high sensitivity CRP (hsCRP) may be elevated in SLE and is associated with organ damage. Objective: To evaluate the association between hsCRP levels and SLE disease activity index (SLEDAI). Methods: This cross-sectional study was conducted in 40 SLE patients. The SLEDAI was calculated and the hsCRP level was measured in the serum. Correlation between hsCRP levels and SLEDAI was assessed. Relationship of hsCRP levels with individual components of SLEDAI was also analyzed. Results: Out of 40 patients, 38 (95%) were female. The mean age was 28.15 years. The mean SLEDAI was 27.4 ± 17.8, indicating that most of the patients had high disease activity. The mean hsCRP levels were 6.64 ± 5.09 mg/L. hsCRP levels and SLEDAI showed strong positive correlation (Pearson's correlation coefficient r ¼ 0.91; p < 0.0001). hsCRP levels were higher in patients with serositis, nephritis, nervous system manifestations and immunological abnormalities. Conclusion: hsCRP levels reflect SLE disease activity and are higher in patients with major organ involvement.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed434    
    Printed8    
    Emailed0    
    PDF Downloaded53    
    Comments [Add]    
    Cited by others 1    

Recommend this journal