Tab Application Banner
  • Users Online: 324
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2013  |  Volume : 8  |  Issue : 2  |  Page : 65-67

High sensitivity C-reactive protein (hsCRP): Association with clinical subsets in systemic lupus erythematosus (SLE) patients from Western India


1 Department of Clinical & Experimental Immunology, National Institute of Immunohaematology, Indian Council of Medical Research, Maharashtra, India
2 Department of Medicine, King Edward Memorial Hospital, Mumbai 400 012, Maharashtra, India

Correspondence Address:
Anjali Rajadhyaksha
Department of Medicine, King Edward Memorial Hospital, Mumbai 400 012, Maharashtra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.injr.2013.03.007

Rights and Permissions

Background: High-sensitivity C-reactive protein (hsCRP) is a marker of systemic inflam- mation. hsCRP have been related to disease presence and clinical activity in systemic lupus erythematosus (SLE). Aim: To understand the association between hsCRP and SLE disease manifestations and other associated immune parameters. Material & methods: One hundred and ten SLE patients were studied and SLE disease activity was evaluated by SLE Disease Activity Index (SLEDAI). Among these 42.7% patients had lupus nephritis (LN). hsCRP and complement levels were detected by nephelometer. Results: A total of 40/110 (36.4%) had elevated hsCRP levels. High CRP was associated with presence of infection (p < 0.001) Patients having bacterial, parasitic and viral infections had elevated levels of hsCRP. LN patients showed slightly higher hsCRP levels (29.3 ± 29.9 mg/L than non-LN group (27.3 ± 21.3 mg/L) but this difference was not significant. Patients with raised hsCRP levels showed a higher prevalence of low complement levels as compared to patients with normal CRP levels (p ¼ 0.03). Conclusion: Elevated hsCRP levels were found to be associated with infections in SLE pa- tients and low complement levels. Elevated hsCRP levels can be used as a marker of active infection in SLE patients.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed452    
    Printed13    
    Emailed0    
    PDF Downloaded67    
    Comments [Add]    
    Cited by others 1    

Recommend this journal