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Year : 2013  |  Volume : 8  |  Issue : 2  |  Page : 65-67

High sensitivity C-reactive protein (hsCRP): Association with clinical subsets in systemic lupus erythematosus (SLE) patients from Western India

1 Department of Clinical & Experimental Immunology, National Institute of Immunohaematology, Indian Council of Medical Research, Maharashtra, India
2 Department of Medicine, King Edward Memorial Hospital, Mumbai 400 012, Maharashtra, India

Correspondence Address:
Anjali Rajadhyaksha
Department of Medicine, King Edward Memorial Hospital, Mumbai 400 012, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.1016/j.injr.2013.03.007

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Background: High-sensitivity C-reactive protein (hsCRP) is a marker of systemic inflam- mation. hsCRP have been related to disease presence and clinical activity in systemic lupus erythematosus (SLE). Aim: To understand the association between hsCRP and SLE disease manifestations and other associated immune parameters. Material & methods: One hundred and ten SLE patients were studied and SLE disease activity was evaluated by SLE Disease Activity Index (SLEDAI). Among these 42.7% patients had lupus nephritis (LN). hsCRP and complement levels were detected by nephelometer. Results: A total of 40/110 (36.4%) had elevated hsCRP levels. High CRP was associated with presence of infection (p < 0.001) Patients having bacterial, parasitic and viral infections had elevated levels of hsCRP. LN patients showed slightly higher hsCRP levels (29.3 ± 29.9 mg/L than non-LN group (27.3 ± 21.3 mg/L) but this difference was not significant. Patients with raised hsCRP levels showed a higher prevalence of low complement levels as compared to patients with normal CRP levels (p ¼ 0.03). Conclusion: Elevated hsCRP levels were found to be associated with infections in SLE pa- tients and low complement levels. Elevated hsCRP levels can be used as a marker of active infection in SLE patients.

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