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REVIEW ARTICLE
Year : 2013  |  Volume : 8  |  Issue : 2  |  Page : 73-78

Renal involvement in ANCA associated vasculitis


1 Department of Internal Medicine, Armed Forces Medical College, Pune 411040, India
2 Department of Pathology, Armed Forces Medical College, Pune 411040, India

Correspondence Address:
Subramanian Shankar
Department of Internal Medicine, Armed Forces Medical College, Pune 411040
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.injr.2013.04.003

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Kidney is involved in upto 75-80% of various ANCA associated vasculitis (AAV) and re- mains the major cause of mortality and morbidity. The classic clinical presentation is that of rapidly progressive renal failure with cresenteric glomerulonephritis being its pathologic correlate. ANCA positivity has been implicated in the pathogenesis and is useful for diagnosis. The treatment of renal AAV involves the use of steroids in combination with other immunosuppressive agents like cyclophosphamide to induce remission followed by maintenance therapy with a less potent agent like azathioprine. Plasmapharesis has a definite role especially in presence of renal failure while Rituximab is emerging as a promising alternative for remission induction.


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