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ORIGINAL ARTICLE
Year : 2013  |  Volume : 8  |  Issue : 4  |  Page : 155-160

Evaluation of dyslipidaemia in patients with rheumatoid arthritis in South Indian population


1 Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences, Tirupati 517507, India
2 Department of Medicine, Sri Venkateswara Institute of Medical Sciences, Tirupati 517507, India

Correspondence Address:
Srinivasa Rao V. L .N. Pemmaraju
Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences, Tirupati 517507
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.injr.2013.06.006

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Background: Rheumatoid arthritis (RA) is associated with increased cardiovascular morbidity and mortality which is mainly due to accelerated atherosclerosis. The inflam- mation in rheumatoid arthritis is likely to alter the lipid profile in these patients resulting in dyslipidaemia which is an important cardiovascular disease (CVD) risk factor. Material and methods: 46 patients diagnosed with RA as per 1987 revised American Rheu- matology Association criteria were included in the study. Of the 46 patients, 24 were newly diagnosed RA patients and 22 patients were undergoing treatment with a combination of DMARDs with (n ¼ 14) or without (n ¼ 8) corticosteroids. 46 age and sex matched healthy subjects were included as controls. Total cholesterol (TC), triglycerides, HDL cholesterol, lDL cholesterol, apolipoprotein A-1 (apo A-1), apolipoprotein B (apo B) and lipoprotein(a) (Lp(a)) were measured. Results: TC, HDL cholesterol and LDL cholesterol levels were similar in all the three study groups. Both groups of patients had significantly elevated triglyceride, apo B and Lp(a) levels compared to controls ( p < 0.05). RA patients undergoing treatment had significantly elevated apo A-1 levels when compared to controls ( p < 0.05). Conclusions: The dyslipidaemia pattern in RA patients in the present study is evident in the form of elevated triglycerides, apo B and Lp(a) levels. The beneficial effects of a higher atheroprotective apo A-1 in patients undergoing treatment may be counteracted by the presence of high triglycerides, apo B and Lp(a).


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