Tab Application Banner
  • Users Online: 2635
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
REVIEW ARTICLE
Year : 2014  |  Volume : 9  |  Issue : 1  |  Page : 14-18

The role of Endoplasmic Reticulum Aminopeptidase 1(ERAP1) in Ankylosing Spondylitis


1 University Health Network, Toronto, ON; University of Toronto, Institute of Medical Science, Toronto, ON, Canada
2 University Health Network, Toronto, ON; University of Toronto, Institute of Medical Science, Toronto, ON; Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, ON, Canada

Correspondence Address:
Nigil Haroon
University Health Network, Toronto, ON; University of Toronto, Institute of Medical Science, Toronto, ON; Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, ON
Canada
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.injr.2014.02.001

Rights and Permissions

Ankylosing Spondylitis (AS) is an inflammatory arthritis that affects the spine resulting in significant deterioration in quality of life of patients as well as accounts for significant socio-economic burden. The etiology of AS is unresolved but appears to involve both environmental and genetic factors. HLA-B27 is the strongest associated gene in AS. Recent Genome Wide Association Studies (GWAS) have implicated several other genes associated with AS thus affirming the complex, oligogenic nature of the disease. Interestingly the Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) gene has the second strongest associ- ation with AS but this association is true only in HLA-B27 positive individuals. As a result there exists a strong possibility that the functional interaction of HLA-B27 and ERAP1 is pathogenic in AS. In this review we preview the biology of HLA-B27 and ERAP1 followed by a discussion of the three main hypotheses of HLA-B27 and ERAP1 interaction in the pathogenesis of AS, namely: the arthritogenic peptide, cell surface homodimer and the unfolded protein response theories of AS pathogenesis. Additionally this review seeks to provide an update on recent advances in the exciting quest to establish the role of HLA-B27 and ERAP1 in the pathogenesis of AS.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed455    
    Printed5    
    Emailed0    
    PDF Downloaded189    
    Comments [Add]    

Recommend this journal