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Year : 2015  |  Volume : 10  |  Issue : 3  |  Page : 117-120

Serum sclerostin levels in rheumatoid arthritis


1 Rheumatology & Rehabilitation Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2 Radiodiagnosis Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
3 Internal Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
4 Clinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Correspondence Address:
Soha Eldessouki Ibrahim
Rheumatology & Rehabilitation Department, Faculty of Medicine, Ain Shams University, Cairo
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.injr.2015.05.002

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Background: Rheumatoid arthritis (RA) is an autoimmune disease that may lead to joint destruction and disability. Wingless (Wnt) pathway is involved in bone formation and has been found to contribute to bone loss in RA. Sclerostin is a key molecule in Wnt pathway. Objective: To study the serum levels of sclerostin in rheumatoid arthritis patients and to study its association with radiological changes. Methods: Forty-five patients with RA and 45 age and gender matched healthy controls were enrolled. Serum sclerostin was measured by ELISA. Modified version of Larsen score was used to assess joint damage in radiographs and Magnetic resonance imaging (MRI) of wrist and hand was assessed for synovitis and bone erosion. Results: Serum sclerostin levels were higher in patients with RA as compared to controls (p < 0.01). Serum sclerostin levels correlated with ESR (r = 0.655), CRP(r = 0.623), modified DAS 28 (r = 0.711), MRI synovitis (r = 0.802) and MRI erosion score (r = 0.832). Conclusion: Increased serum levels of sclerostin may play a role in joint damage and bone erosion in RA.


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