Tab Application Banner
  • Users Online: 544
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2015  |  Volume : 10  |  Issue : 3  |  Page : 121-124

Correlation of QT interval with disease activity in newly detected SLE patients at baseline and during flare


1 Global Hospitals; Department of Rheumatology, Madras Medical College, Chennai, India
2 Department of Rheumatology, Madras Medical College, Chennai, India

Correspondence Address:
Santhanam Sham
Global Hospitals; Department of Rheumatology, Madras Medical College, Chennai
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.injr.2015.03.010

Rights and Permissions

Aim: To study correlation between QT interval parameters (QTc interval & QT dispersion) and disease activity (SLEDAI) in patients with systemic lupus erythematosus (SLE). Methods: The study was done on 100 newly diagnosed patients with SLE and 100 age matched controls from January 2012 to December 2013. A standard 12 lead Electrocardio- gram was obtained. QT interval was calculated from beginning of 'q' wave to end of T wave in lead II or lateral leads (V5, V6). QT dispersion was measured as the difference between maximum and minimum QT intervals. SLE disease activity was measured SLEDAI. Results: Eighty four patients had high disease activity. QTc was > 440 msec in 51 patients and 6 controls. QTd was prolonged in 6 patients and 6 controls. The mean QTc interval among patients (463.30 ± 27.43 msec) was higher than in controls (397.24 ± 31.85 msec; p < 0.001). However the mean QTd among patients (44.40 + 20.61 msec) was similar to that in controls (39.2 + 17.7 msec). Difference of QTc values during severe flare from baseline QTc values was statistically significant (r = 0.863; Pearson's correlation coefficient). Conclusions: Patients with high disease activity have higher prevalence of QTc prolongation, QTc interval may be used as a surrogate marker for assessing disease activity in SLE.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed650    
    Printed9    
    Emailed0    
    PDF Downloaded86    
    Comments [Add]    
    Cited by others 3    

Recommend this journal