Tab Application Banner
  • Users Online: 402
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
REVIEW ARTICLE
Year : 2015  |  Volume : 10  |  Issue : 5  |  Page : 59-63

Granulomatosis with polyangiitis: Indian experience


1 Department of Rheumatology, Fortis Flt Lt Rajan Dhall Hospital, Vasant Kunj, Delhi, India
2 Fortis Hospital, Mohali, Punjab, India

Correspondence Address:
Ashok Kumar
Department of Rheumatology, Fortis Flt Lt Rajan Dhall Hospital, Vasant Kunj, Delhi
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.injr.2015.08.001

Rights and Permissions

Granulomatosis with polyangiitis (GPA) is now a well-recognised clinical entity in India. The earliest description of GPA in India (then called Wegener's granulomatosis) appeared as a single case in a series of 108 cases of systemic vasculitis published in 1985. Later, several short case-series (mostly from northern India) and a number of case reports were published. The number of published cases of GPA from India till date is about 130 (actual burden of disease is certainly much larger as only a few cases get published). The overall clinical profile, response to treatment and long-term outcome of GPA do not differ significantly from what is described in western literature. A female preponderance has been noted in the Indian series, whereas no gender predilection was seen in western series. Although many cases used to masquerade as pulmonary tuberculosis in the past, the situation has improved considerably, with better awareness about the disease and availability of ANCA as a diagnostic test. High relapse rate and significant organ damage continue to pose a challenge. Cyclophosphamide combined with prednisolone is the standard induction regimen. Ritux- imab and its two biosimilars are being increasingly used in the management of refractory cases as well as for induction of remission in certain situations.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1079    
    Printed12    
    Emailed0    
    PDF Downloaded247    
    Comments [Add]    
    Cited by others 2    

Recommend this journal