Tab Application Banner
  • Users Online: 1490
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
TOPICAL REVIEW
Year : 2016  |  Volume : 11  |  Issue : 2  |  Page : 73-77

Takayasu's arteritis


Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, India

Correspondence Address:
Durga Prasanna Misra
Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.injr.2016.04.001

Rights and Permissions

Takayasu's arteritis (TA) is a granulomatous large vessel vasculitis more common in India. We review recently published literature in this field over the past year. Multiple reports based on genetic data and studies in peripheral blood of patients with TA suggest perturba- tion of the Th17-IL17 axis in these patients, which may be amenable to targeted therapy. Abnormal pro-atherogenic lipid profiles in TA (increased LDL-C and Apo A1, decreased HDL- C and Apo-B) may drive disease process in TA. Clinically inactive TA at diagnosis has been shown to relapse and progress angiographically on follow-up. TA seems to be associated with poorer pregnancy outcomes. Recent papers on 18 fluoro-deoxyglucose positron emis- sion tomography and contrast-enhanced magnetic resonance angiographic scoring of TA suggest the need to incorporate these techniques into clinical assessment tools to delineate the actual extent of vascular involvement in TA. Recent advances in therapeutics indicate that leflunomide may be an effective disease-modifying agent in TA, whereas a large retrospective French cohort suggests relatively safety and efficacy of biologic agents target- ing tumour necrosis factor alpha or interleukin-6 in patients with TA.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed442    
    Printed9    
    Emailed0    
    PDF Downloaded208    
    Comments [Add]    

Recommend this journal