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ORIGINAL ARTICLE
Year : 2016  |  Volume : 11  |  Issue : 2  |  Page : 82-85

Serum adiponectin and its impact on disease activity and radiographic joint damage in early rheumatoid arthritis - A cross-sectional study


Department of Rheumatology, Nizams Institute of Medical Sciences, Hyderabad, India

Correspondence Address:
Srinivasa Chennareddy
Department of Rheumatology, Nizams Institute of Medical Sciences, Hyderabad
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.injr.2016.01.006

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Objective: To study the level of serum adiponectin in steroid and DMARD naïve early rheumatoid arthritis patients and its correlation with disease activity and radiographic damage. Materials and methods: Forty-three patients fulfilling ACR 2010 criteria for rheumatoid ar- thritis, with disease duration less than 2 years and 25 age, sex and BMI matched controls were recruited for the study between July 2012 to January 2013. Demographic data, tender joint count, swollen joint count, erythrocyte sedimentation rate, and rheumatoid factor status were recorded. Radiographs of hands and feet were obtained. BMI, DAS28-ESR and HAQ-DI were calculated. Serum concentration of adiponectin was measured by ELISA. Results: Among 43 early rheumatoid patients (38 females), 18 had erosive disease. There were 25 controls (21 females). Median serum adiponectin levels (14 mg/ml), range (8.5-19) were significantly higher in early RA patients compared to controls (10.2 mg/ml), range (7.9-13.5) ( p = 0.02). No difference in the adiponectin levels between erosive and nonerosive disease was noted. No correlation to duration of disease, BMI, waist hip ratio and disease activity was noted. Conclusion: In this study, while exploring the levels of adiponectin in a cohort of early RA, we observed increased serum adiponectin concentration in steroid and DMARD naοve early rheumatoid arthritis patients.


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