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REVIEW ARTICLE
Year : 2017  |  Volume : 12  |  Issue : 6  |  Page : 142-148

The pathogenesis of scleroderma


1 Division of Rheumatology, Perelman School of Medicine, University of Philadelphia, Philadelphia, Pennsylvania, USA
2 Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

Correspondence Address:
Latika Gupta
Division of Rheumatology, Perelman School of Medicine, University of Philadelphia, Philadelphia, Pennsylvania
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-3698.219083

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Systemic sclerosis (SSc) results from the complex interplay between the immune system, vasculature and tissue-repair mechanisms. Endothelial injury is the prime event; environmental triggers in the susceptible individual trigger the pathologic process, which translates into fibrosis. The outcome of SSc is not as bleak as it looked a couple of decades ago. With a greater understanding of older pathways, as well as elucidation of newer ones, the potential targets to block and even reverse fibrosis bring around a revolution in the way we look at this once dreaded disease.


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