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REVIEW ARTICLE
Year : 2017  |  Volume : 12  |  Issue : 6  |  Page : 149-155

Biomarkers in scleroderma: Current status


1 Division of Rheumatology, Perelman School of Medicine, University of Philadelphia, Philadelphia, PA, USA
2 Department of Medicine, BJ Medical College, Pune, Maharashtra, India
3 Department of Rheumatology and Clinical Immunology, Starcare Hospital, Kozhikode, Kerala, India

Correspondence Address:
Sukesh Edavalath
Department of Rheumatology and Clinical Immunology, Starcare Hospital, Kozhikode - 673 017, Kerala
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-3698.219087

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Scleroderma is an autoimmune disease characterized by indolent obliterative vasculopathy and widespread fibrosis. The two main morphological manifestations of the disease overlap and may make it difficult to separate activity from damage. Many patients, especially those with the limited subset of the disease, have an indolent course without clear-cut inflammatory manifestations. There is a felt need for validated biomarkers, which can differentiate activity from damage, and yet be sensitive to change with therapy. Multiplex arrays of biomarkers have ushered an era of targeted or personalized medicine based on phenotypic characteristics in an individual.


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