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REVIEW ARTICLE
Year : 2017  |  Volume : 12  |  Issue : 6  |  Page : 171-179

Mimics of scleroderma


1 Centre for Arthritis and Rheumatism Excellence, Nettoor, India
2 Department of Dermatology, Amrita Institute of Medical Science, Kochi, Kerala, India

Correspondence Address:
D Padmanabha Shenoy
Centre for Arthritis and Rheumatism Excellence, Nettoor, NH47, Kochi, Kerala - 682 040
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-3698.219086

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Systemic sclerosis is a rare autoimmune connective tissue disorder characterised typically by tightening and tethering of skin. However, several other disorders are also characterised by hardening and thickening of skin. These mimics can be potentially confused with systemic sclerosis, leading to a misdiagnosis. This review describes the aetiopathogenesis, clinical features and treatment of Morphea (localised scleroderma), Scleredema, Scleromyxoedema, Eosinophilic fasciitis, Nephrogenic Systemic Fibrosis, Diabetic Cheiroarthropathy, chronic GVHD, POEMS syndrome and drug induced scleroderma like illness. A careful and thorough clinical assessment is essential in order to differentiate these mimics from each other and from systemic sclerosis, establish the diagnosis, and initiate appropriate treatment.


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