Tab Application Banner
  • Users Online: 714
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2019  |  Volume : 14  |  Issue : 4  |  Page : 283-289

The increased erythrocyte membrane n-6/n-3 fatty acids ratio and inflammatory markers in patients with psoriasis


1 Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
2 Dermatology and Venereology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
3 Department of Dermatology and Venereology, Trabzon Vakfıkebir Health Ministry Hospital, Trabzon, Turkey

Correspondence Address:
Dr. Serap Ozer Yaman
Department of Medical Biochemistry, Karadeniz Technical University, Faculty of Medicine, Trabzon
Turkey
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/injr.injr_84_19

Rights and Permissions

Background: Psoriasis is a common chronic, recurrent inflammatory skin disorder. Omega-3 fatty acids exhibit low inflammatory effects, while n-6 fatty acids display high inflammatory effects. The purpose of this preliminary study was to determine erythrocyte membrane n-6/n-3 fatty acid ratio values and their relationship with plasma inflammatory mediators in patients with psoriasis. Methods: The study groups consisted of thirty patients with psoriasis and 36 healthy controls. Analyses of fatty acids in the erythrocyte membrane were performed using gas chromatography and a flame ionization detector. Serum sample inflammation parameters (C-reactive protein [CRP]), erythrocyte sedimentation rate (ESR), and interleukin-6 (IL-6) were also analyzed. Results: The erythrocyte membrane n-6/n-3 fatty acid ratio was significantly higher in the psoriatic group compared to the healthy control group (P = 0.004). CRP, ESR, and IL-6 levels were also higher (P < 0.05) in the psoriatic group. The n-6/n-3 ratio was positively correlated with CRP and IL-6 levels in the psoriatic group (rho = 0.687, P= 0.0001 and rho = 0.542, P= 0.002, respectively). ROC curve analyses of CRP, ESR, IL6, and n6/n3 ratio values in patients with psoriasis performed similarly. Conclusion: This preliminary study indicates that erythrocyte membrane n6/n3 fatty acid ratio was increased and showed correlations with plasma CRP and IL-6 in patients with psoriasis. Receiver operating characteristic analysis indicates that the n6/n3 ratio (area underthe curve = 0.699) may be a suitable inflammatory marker for further exploration in psoriasis. Erythrocyte membrane n-6/n-3 fatty acid ratio may be used as one of the pro-inflammatory markers in psoriasis.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed698    
    Printed22    
    Emailed0    
    PDF Downloaded83    
    Comments [Add]    

Recommend this journal