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REVIEW ARTICLE
Year : 2020  |  Volume : 15  |  Issue : 5  |  Page : 6-12

Current concepts in the pathogenesis of spondyloarthritis


University Hospitals of Leicester NHS Trust, Leicester, UK

Correspondence Address:
Dr. Arumugam Moorthy
Consultant Rheumatologist, University Hospitals of Leicester NHS Trust, Leicester
UK
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-3698.284745

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Pathogenesis of spondyloarthritis (SpA) is multifactorial and still not understood entirely. The role of genetics including human leukocyte antigen B27 has been investigated extensively, which along with genome-wide association studies has helped us understand and postulate various theories. Environmental factors including gut dysbiosis, mechanical stress, and transduction have been implicated in the pathogenesis. Recently, the interleukin (IL)-17/IL-23 pathway has been major focus due to it being therapeutic target. Herein, we reviewed various recent developments and current concepts in the pathogenesis of SpA.


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