Indian Journal of Rheumatology
Volume 6, Issue 4 , Pages 168-172, December 2011

Role of vascular endothelial growth factor and monocyte chemoattractant protein-1 in Behçet's disease

  • Soha ElDessouki Ibrahim

      Affiliations

    • Lecturer, Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    • Corresponding Author InformationCorrespondence: Dr. Soha ElDessouki Ibrahim
    • ,
  • Heba Fawzi Elshishtawy

      Affiliations

    • Assistant Professor, Department of Rheumatology, Ain Shams University, Cairo, Egypt
    • ,
  • Amir HelmySamy

      Affiliations

    • Lecturer, Department of Internal Medicine, Ain Shams University, Cairo, Egypt
    • ,
  • Zeinab Ali Galal

      Affiliations

    • Lecturer, Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Article Outline

Abstract 

Objectives

To study the role of vascular endothelial growth factor (VEGF) and monocyte chemoattractant protein-1 (MCP-1) in Behçet's disease and their relation to clinical manifestations particularly vascular manifestations and disease activity.

Methods

Forty Behçet's disease patients (32 males, 8 females), diagnosed according to the criteria proposed by the International Study Group for Behçet's disease were assessed clinically and serum VEGF and MCP-1 were measured by enzyme-linked immunosorbent assay.

Results

Serum VEGF and MCP-1 levels were detected in patients and control groups with highly significant increase in Behçet's group. A highly significant increase in the level of serum VEGF and MCP-1 was found in patients with vascular manifestations compared to those without vascular complications. A significant increase in the level of VEGF and MCP-1 was found in patients with active disease compared to inactive.

Conclusion

Our findings suggest that serum VEGF and MCP-1 levels are elevated in active Behçet's patients and in patients with vascular complications. So, we conclude that VEGF and MCP-1 play a crucial role in the pathogenesis of vascular complications of Behçet's disease. Therefore, the serum levels of these cytokines serve to predict a possible acute thrombosis in Behçet's disease.

Keywords:  Beçhet , VEGF , MCP-1

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References 

  1. Suzuki KM , Suzuki N . Behçet's disease . Clin Exp Med . 2004;4:10–20
  2. Yang P , Fang W , Meng Q , Ren Y , Xing L , Kijlstra A . Clinical features of Chinese patients with Behçet's disease . Ophthalmology . 2008;115:312–318 e314.
  3. Sakane T , Takeno M , Suzuki N , Inaba G . Behçet's disease . N Engl J Med . 1999;341:1284–1291
  4. Hou S , Yang P , Du L , Jiang Z , Mao L , Shu QL , et al.   Mono-cyte chemoattractant protein-1-2518 A/G single nucleotide polymorphism in Chinese Han patients with ocular Behçet's disease . Human Immunol . 2010;71:79–82
  5. Houman MH , Ben Ghorbeli I , Khiari Ben Salah I , Lamloum M , Ben Ahmed M , Milled M . Deep venous thrombosis in Behçet's disease . Clin Exp Rheumatol . 2001;19:548–550
  6. Drouart M , Saas P , Billot M , Cedoz JP , Tiberghien P , Wendling D , et al.   High serum vascular endothelial growth factor correlates with disease activity of spondyloarthropathies . Clin Exp Immunol . 2003;132:158–162
  7. Daly C , Rollins BJ . Monocytes chemoattractant protein-1 (CCL2) in inflammatory disease and adaptive immunity: therapeutic opportunities and controversies . Microcirculation . 2003;10:247–257
  8. Van Royen N , Piek JJ , Buschmann I , Hoefer I , Voskuli W , Schaper W . Stimulation of arteriogenesis: a new concept for the treatment of arterial occlusive disease . Cardiovasc Res . 2001;49:543–553
  9. Erdem F , Gundogdu M , Kiki O , Sari RA , Kiziltunc A . Vascular endothelial and basic fibroblast growth factor serum levels in patients with Behçet's disease . Rheumatol Int . 2005;24:599–603
  10. Bozoglu E , Dinc A , Erdem H , Pay S , Simsek I , Kocar IH . Vascular endothelial growth factor and monocyte chemoattractant protein-1 in Behçet's patients with venous thrombosis . Clin Exp Rheumatol . 2005;23(Suppl 38):42–48
  11. International Study Group for Behcet's disease  . Criteria for diagnosis of Behçet's disease . Lancet . 1990;335:1078–1080
  12. Cekmen M , Evereklioglu CE , Er H , Inaloz HS , Doganay S , Turkoz Y , et al.   Vascular endothelial growth factor levels are increased and associated with disease activity in patients with Behçet's syndrome . Int J Dermtol . 2003;42:870–875
  13. Shaker O , Ay El-Deen MA , El Hadidi H , Grace BD , El Sherif H , Abdel Halim A . The role of heat shock protein 60, vascular endothelial growth factor and antiphospholipid antibodies in Behçet's disease . Clin Lab Invest . 2007;156:32–37
  14. Kiraz S , Ertenli H , Ozturk MA , Haznedaroglu IC , Celic I , Calguneri M . Pathological haemostasis and prothrombotic state in Behçet's disease . Thromb Res . 2002;105:125–135
  15. Ames PR , Stever A , Pap AP , Denman AM . Thrombosis in Behçet's disease: a retrospective survey from a single UK centre . Rheumatology (Oxford) . 2001;40:652–655
  16. Roscoe WA , Welsh ME , Carter DE , Karlik SJ . VEGF and angiogenesis in acute and chronic MOG (35-55) peptides induced EAE . J Neuro Immunol . 2009;209:6–15
  17. Klagsbrun M , D'amore PA . Vascular endothelial growth factor and its receptors . Cytokine Growth Factor Rev . 1996;7:259–270
  18. Baggiolini M . Chemokines in Behçet's disease, a field to be explored as a potential basis for therapy . Adv Exp Med Biol . 2003;528:239–243
  19. Meloney JP , Silliman CC , Ambruso DR , Wang J , Tuder RM , Voelkel NF . In vitro release of vascular endothelial during platelets aggregation . Am J Physiol . 1998;275:H1054–H1056
  20. Sancak B , Onder M , Oztas MO , Bukan N , Gurer MA . Nitric oxide levels in Behçet's disease . J Eur Acad Dermatol Venereal . 2003;17:7–9
  21. Ozdamar Y , Berker N , Bahar G , Soykan E , Bicer T , Ozkan SS , et al.   Inflammatory mediators and posterior segment involvement in ocular Behçet disease . Eur J Ophthalmol . 2009;19:998–1003
  22. Kamoun M , Houman MH , Hamzaoui A , Hamzaoui K . Vascular endothelial growth factor gene polymorphism and serum levels in Behçet's disease . Tissue Antigens . 2008;72:581–587
  23. Cho ML , Kim JY , Ko HJ , Kim YH , Kim WV , Cho CS , et al.   The MCP-1 promoter-2518 polymorphism in Behçet's disease: correlation between allele types, MCP-1 production and clinical symptoms among Korean patients . Autoimmunity . 2004;37:77–80
  24. Yamada M , Kim S , Egashira K , Takeya M , Ikeda T , Mimura O , et al.   Molecular mechanism and role of endothelial monocyte chemoattractant protein-1 induction by vascular endothelial growth factor . Arterioscler Thromb Vasc Biol . 2003;23:1996–2001

PII: S0973-3698(11)60202-1

doi:10.1016/S0973-3698(11)60202-1

Indian Journal of Rheumatology
Volume 6, Issue 4 , Pages 168-172, December 2011

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