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A study of serum YKL-40 and its correlation with traditional biomarkers in rheumatoid arthritis patients

 Department of Biochemistry, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India

Correspondence Address:
Vinod Narayan,
Department of Biochemistry, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai - 600 116, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/injr.injr_44_19

Background: This study was aimed to measure the serum levels of YKL-40 among early and late rheumatoid arthritis (RA) patients along with other disease activity measures in RA patients. Materials and Methods: It was a cross-sectional study involving 152 RA patients based on the 1987 American College of Rheumatology criteria for the diagnosis of RA and 68 age- and sex-matched healthy controls. The patient group was further subdivided into 75 early (<2 years disease duration) and 77 late (>2 years) RA patients based on the duration of the disease. Clinical examination was performed on RA patients, and traditional markers to measure the disease activity such as Disease Activity Score (DAS)-28, Visual Analog Score (VAS), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), anti-cyclic citrullinated peptide (CCP), and rheumatoid factor (RF) were assessed. Serum YKL-40 level was measured using ELISA method. All the values were expressed as median (25th–75th percentile). Results: In our study, there was a significant increase in serum YKL-40 level in RA patients (200.8 [141.24–282.7] ng/ml) compared to healthy controls (82.2 [49.01–123.78] ng/ml) with P < 0.001. There was no significant difference in serum YKL-40 levels among early and late RA patients. The traditional inflammatory markers such as ESR, CRP, and measures of disease activity such as DAS-28 and VAS were significantly increased in late RA patients than early RA (P < 0.001). Serum YKL-40 levels were not correlated with disease activity measures such as DAS-28, VAS, CRP, and ESR in RA patients. Conclusion: Serum YKL-40 level was significantly higher in RA. However there was no difference between early and late RA. It does not correlate with measures of disease activity.

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