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Adiponectin and rheumatoid arthritis

1 Sanitation 1 Medical Academic Center, Bangkok, Thailand
2 Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India

Correspondence Address:
Beuy Joob,
Sanitation 1 Medical Academic Center, Bangkok
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/injr.injr_133_19

How to cite this URL:
Joob B, Wiwanitkit V. Adiponectin and rheumatoid arthritis. Indian J Rheumatol [Epub ahead of print] [cited 2019 Nov 20]. Available from:

Dear Editor,

We read the publication on “Serum adiponectin levels in patients with rheumatoid arthritis” with great interest.[1] We would like to share ideas on this report. Veluri et al. concluded that “serum adiponectin concentration is decreased in rheumatoid arthritis (RA) patients and was not associated with disease activity.“[1] In a recent meta-analysis, Cao et al. found the relationship between serum leptin level and disease activity index in RA.[2] Nevertheless, the measurement has to be the baseline level before any case management.[2],[3] In addition, the predictive property of adiponectin is good only if the patient has normal weight.[3] The lack of association in the study by Veluri et al. might be due to the effect of disease management. In addition, the adiponectin might be affected by serum lipid and renal function of the patients.[4]

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  References Top

Veluri G, Vinapamula KS, Rao S, Kommireddy S, Manohar SM, Pasupuleti P. Serum adiponectin levels in patients with rheumatoid arthritis. Indian J Rheutamol 2019;4:119-22.  Back to cited text no. 1
Cao H, Lin J, Chen W, Xu G, Sun C. Baseline adiponectin and leptin levels in predicting an increased risk of disease activity in rheumatoid arthritis: A meta-analysis and systematic review. Autoimmunity 2016;49:547-53.  Back to cited text no. 2
Xibillé-Friedmann DX, Ortiz-Panozo E, Bustos Rivera-Bahena C, Sandoval-Ríos M, Hernández-Góngora SE, Dominguez-Hernandez L. Leptin and adiponectin as predictors of disease activity in rheumatoid arthritis. Clin Exp Rheumatol 2015;33:471-7.  Back to cited text no. 3
Targońska-Stepniak B, Dryglewska M, Majdan M. Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis. Rheumatol Int 2010;30:731-7.  Back to cited text no. 4


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