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LETTER TO EDITOR
Ahead of print publication  

Response to comments on “bone mineral density is decreased in patients with systemic sclerosis and correlates with serum intact parathormone levels: A cross-sectional study”


1 Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India
2 Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
Shefali Sharma,
Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/injr.injr_140_19



How to cite this URL:
Sharma S, Dhooria A, Singh T. Response to comments on “bone mineral density is decreased in patients with systemic sclerosis and correlates with serum intact parathormone levels: A cross-sectional study”. Indian J Rheumatol [Epub ahead of print] [cited 2019 Dec 7]. Available from: http://www.indianjrheumatol.com/preprintarticle.asp?id=270739



Dear Editor,

We thank Prof. Mahmood Dhahir Al-Mendalawi for his valuable comments. As already stated, dual-energy X-ray absorptiometry (DXA) scan was performed using Hologic viewer 6.0 (ModelDiscovery A [S/N 87292]). This machine gives an option to select the ethnicity. We could choose between Asian, Hispanic, Caucasian, or African American. We chose the Asian option.

There is only one study done by the Indian Council of Medical Research (ICMR), which compares the normative data for bone mineral density (BMD) measured by DXA scanning. In this study, 2976 individuals (men 341 and women 2757) (mean age ± standard deviation = 62·2 ± 7·2 years), including 316 with low-impact hip fracture, were chosen. Two thousand one hundred and ninety-nine patients were from the hospital database, and 461 were healthy postmenopausal women from the community.[1] This study was undertaken to look at an agreement between the Hologic database based on BMD normative data in Caucasians and the ICMR database in defining osteoporosis in individuals with or without hip fracture. An almost perfect agreement existed between the two databases for the diagnosis of osteoporosis at the hip (κ = −0·82, P < 0·0001) in all individuals, and a moderate relationship existed in those with hip fracture (κ = −0·65, P < 0·0001). Although the interpretation of DXA results requires population-specific references, this study showed that a good correlation existed between the reference values. For this particular reason, we used these reference values in our study.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Shetty S, Kapoor N, Naik D, Asha HS, Thomas N, Paul TV, et al. The impact of the hologic vs. the ICMR database in diagnosis of osteoporosis among South Indian subjects. Clin Endocrinol (Oxf) 2014;81:519-22.  Back to cited text no. 1
    




 

 
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