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ORIGINAL ARTICLE
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Impact of obesity on leptin, leptin receptor gene polymorphism, and some adipokines in egyptian patients with knee osteoarthritis


1 Department of Organic Chemistry, Faculty of Science, Menofia University, Shebin El-Kom, Egypt
2 Department of Medicinal Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt
3 Department of Rheumatology and Rehabilitation, Faculty of Medicine, Tanta University, Tanta, Egypt

Correspondence Address:
Aya A Al-Ashwah,
Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Kom
Egypt
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/injr.injr_71_19

Aim: The aim of this study was to investigate the role of leptin receptor (LEPR) gene polymorphism and adipokines in the pathogenesis of knee osteoarthritis (OA) in Egyptian female patients. Materials and Methods: Ninety-five Egyptian females were classified into three groups: group I (control): 32 healthy females, Group II: included 30 non obese knee osteoarthritic patients and Group III: included 33 obese knee osteoarthritic patients. Genotyping of rs1137101 at LEPR gene was analyzed using allelic discrimination assay by real-time polymerase chain reaction technique, and then, adipokines and nitric oxide (NO) levels were measured. Results: The frequency of GG genotype was found to be significantly higher in Group III when compared to Group II and controls (26% to 4%, 1%) (P < 0.001), while AA genotype was the most frequent in the control group (75%) (P < 0.001). rs1137101 was correlated with knee OA in the dominant genetic model (GG + GA vs. AA) in Group II (odds ratio = 8, 95% CI [2.6–24.2], P <.001). Moreover, there was a significant increase in serum levels of leptin, resistin, and NO with a concomitant decrease in adiponectin level in Group III as compared to the other two groups confirming the role of these adipokines in OA. Conclusion: Our findings suggested that the genetic variation in rs1137101 is involved in the pathogenesis of both obesity and knee OA in Egyptian female patients. In addition, it seems that adipokines and oxidative stress are important factors linking obesity, adiposity, and inflammation in OA.


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    -  H. Abdel-Rahman AA
    -  Hamouda HE
    -  Zeid IF
    -  El-Barbary AM
    -  Al-Ashwah AA
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