Indian Journal of Rheumatology

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 8  |  Issue : 2  |  Page : 65--67

High sensitivity C-reactive protein (hsCRP): Association with clinical subsets in systemic lupus erythematosus (SLE) patients from Western India


Vandana Pradhan1, Anjali Rajadhyaksha2, Manisha Patwardhan1, Prathamesh Surve1, Nivedita Dhavale1, Pallavi Pandit1, Kanjaksha Ghosh1 
1 Department of Clinical & Experimental Immunology, National Institute of Immunohaematology, Indian Council of Medical Research, Maharashtra, India
2 Department of Medicine, King Edward Memorial Hospital, Mumbai 400 012, Maharashtra, India

Correspondence Address:
Anjali Rajadhyaksha
Department of Medicine, King Edward Memorial Hospital, Mumbai 400 012, Maharashtra
India

Background: High-sensitivity C-reactive protein (hsCRP) is a marker of systemic inflam- mation. hsCRP have been related to disease presence and clinical activity in systemic lupus erythematosus (SLE). Aim: To understand the association between hsCRP and SLE disease manifestations and other associated immune parameters. Material & methods: One hundred and ten SLE patients were studied and SLE disease activity was evaluated by SLE Disease Activity Index (SLEDAI). Among these 42.7% patients had lupus nephritis (LN). hsCRP and complement levels were detected by nephelometer. Results: A total of 40/110 (36.4%) had elevated hsCRP levels. High CRP was associated with presence of infection (p < 0.001) Patients having bacterial, parasitic and viral infections had elevated levels of hsCRP. LN patients showed slightly higher hsCRP levels (29.3 ± 29.9 mg/L than non-LN group (27.3 ± 21.3 mg/L) but this difference was not significant. Patients with raised hsCRP levels showed a higher prevalence of low complement levels as compared to patients with normal CRP levels (p ¼ 0.03). Conclusion: Elevated hsCRP levels were found to be associated with infections in SLE pa- tients and low complement levels. Elevated hsCRP levels can be used as a marker of active infection in SLE patients.


How to cite this article:
Pradhan V, Rajadhyaksha A, Patwardhan M, Surve P, Dhavale N, Pandit P, Ghosh K. High sensitivity C-reactive protein (hsCRP): Association with clinical subsets in systemic lupus erythematosus (SLE) patients from Western India .Indian J Rheumatol 2013;8:65-67


How to cite this URL:
Pradhan V, Rajadhyaksha A, Patwardhan M, Surve P, Dhavale N, Pandit P, Ghosh K. High sensitivity C-reactive protein (hsCRP): Association with clinical subsets in systemic lupus erythematosus (SLE) patients from Western India . Indian J Rheumatol [serial online] 2013 [cited 2019 Nov 22 ];8:65-67
Available from: http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2013;volume=8;issue=2;spage=65;epage=67;aulast=Pradhan;type=0