Indian Journal of Rheumatology

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 8  |  Issue : 4  |  Page : 155--160

Evaluation of dyslipidaemia in patients with rheumatoid arthritis in South Indian population


Kiranmayi S Vinapamula1, Suchitra M Manohar1, Aparna R Bitla1, Rajyalakshmi Kanduri1, Siddartha Kumar Bhattaram2, Srinivasa Rao V. L .N. Pemmaraju1 
1 Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences, Tirupati 517507, India
2 Department of Medicine, Sri Venkateswara Institute of Medical Sciences, Tirupati 517507, India

Correspondence Address:
Srinivasa Rao V. L .N. Pemmaraju
Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences, Tirupati 517507
India

Background: Rheumatoid arthritis (RA) is associated with increased cardiovascular morbidity and mortality which is mainly due to accelerated atherosclerosis. The inflam- mation in rheumatoid arthritis is likely to alter the lipid profile in these patients resulting in dyslipidaemia which is an important cardiovascular disease (CVD) risk factor. Material and methods: 46 patients diagnosed with RA as per 1987 revised American Rheu- matology Association criteria were included in the study. Of the 46 patients, 24 were newly diagnosed RA patients and 22 patients were undergoing treatment with a combination of DMARDs with (n ¼ 14) or without (n ¼ 8) corticosteroids. 46 age and sex matched healthy subjects were included as controls. Total cholesterol (TC), triglycerides, HDL cholesterol, lDL cholesterol, apolipoprotein A-1 (apo A-1), apolipoprotein B (apo B) and lipoprotein(a) (Lp(a)) were measured. Results: TC, HDL cholesterol and LDL cholesterol levels were similar in all the three study groups. Both groups of patients had significantly elevated triglyceride, apo B and Lp(a) levels compared to controls ( p < 0.05). RA patients undergoing treatment had significantly elevated apo A-1 levels when compared to controls ( p < 0.05). Conclusions: The dyslipidaemia pattern in RA patients in the present study is evident in the form of elevated triglycerides, apo B and Lp(a) levels. The beneficial effects of a higher atheroprotective apo A-1 in patients undergoing treatment may be counteracted by the presence of high triglycerides, apo B and Lp(a).


How to cite this article:
Vinapamula KS, Manohar SM, Bitla AR, Kanduri R, Bhattaram SK, Pemmaraju SV. Evaluation of dyslipidaemia in patients with rheumatoid arthritis in South Indian population .Indian J Rheumatol 2013;8:155-160


How to cite this URL:
Vinapamula KS, Manohar SM, Bitla AR, Kanduri R, Bhattaram SK, Pemmaraju SV. Evaluation of dyslipidaemia in patients with rheumatoid arthritis in South Indian population . Indian J Rheumatol [serial online] 2013 [cited 2019 Dec 5 ];8:155-160
Available from: http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2013;volume=8;issue=4;spage=155;epage=160;aulast=Vinapamula;type=0