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  Indian J Med Microbiol
 

Figure 1: Endothelial dysfunction. Endothelial dysfunction is a common end point for a variety of different insults. These include systemic inflammation characteristic of many rheumatic diseases as well as traditional cardiovascular risk factors. Although most commonly associated with increased reactive oxygen species, uncoupling of tetrahydrobiopterin (BH4) from endothelial nitric oxide synthase and reduced biosynthesis of nitric oxide, it also involves widespread abnormalities in constitutive endothelial function and predisposes to atherogenesis

Figure 1: Endothelial dysfunction. Endothelial dysfunction is a common end point for a variety of different insults. These include systemic inflammation characteristic of many rheumatic diseases as well as traditional cardiovascular risk factors. Although most commonly associated with increased reactive oxygen species, uncoupling of tetrahydrobiopterin (BH4) from endothelial nitric oxide synthase and reduced biosynthesis of nitric oxide, it also involves widespread abnormalities in constitutive endothelial function and predisposes to atherogenesis