Tab Application Banner
  • Users Online: 403
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2006  |  Volume : 1  |  Issue : 1  |  Page : 8-12

Benign joint hypermobility syndrome: a hospital-based study from northern India

1 Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
2 Department of Physical Medicine & Rehabilitation, All India Institute of Medical Sciences, New Delhi, India
3 Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India
4 Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi, India
5 Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
P Acharya
Department of Medicine, All India Institute of Medical Sciences, New Delhi
Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Objectives: To study the frequency, demography, clinical features and response to treatment of benign joint hypermobility syndrome (BJHS) in a rheumatology clinic at a tertiary referral centre in India and to ascertain the association of hypermobility with musculoskeletal symptoms. Methods: Consecutive adult patients with Beighton score of 5 or more and conforming to Brighton criteria were recruited from the rheumatology clinic over 18 months. Detailed clinical and laboratory work-up was carried out including ophthalmologic and echocardiographic evaluation. Treatment comprised reassurance, physiotherapy and nonsteroidal anti-inflammatory drugs/analgesics. Pain score and patient global assessment were measured at 0, 2 and 12 weeks. The association of hypermobility with musculoskeletal symptoms was ascertained in a case-control study performed separately. Results: Hypermobility (Beighton score > 5) was observed in about 20% (405/2050) of rheumatology referrals. However, only about half of them (204/2050) met the Brighton criteria for BJHS. One hundred BJHS patients (mean age 30 + 9.4 years, female : male = 2.2 : 1) were recruited for detailed study. All had gross hypermobility and knee was the commonest joint involved. Rheumatoid distribution of painful joints often raised suspicion of rheumatoid arthritis (RA) but objective clinical and laboratory findings of RA were lacking. Sixty-one had received a wrong diag- nosis before referral (RA, ankylosing spondylitis, rheumatic fever) and 22 had been taking long-term penicillin prophylaxis for suspected rheumatic fever. About 40% had negligible symptoms after 12 weeks while others continued to suffer from mild to moderate symptoms with no synovitis or joint damage. Case-control study showed greater likelihood of presence of hypermobility amongst the patients referred to the rheumatology clinic with odds ratio = 3.23 (CI = 1.86-5.63, P = 0.000). Conclusions: BJHS is common in Indians and is often mistaken for other rheumatic disorders. There is 3.2 times more likelihood of finding joint hypermobility amongst patients referred to a rheumatology clinic, thereby confirming its association with musculoskeletal complaints.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded67    
    Comments [Add]    

Recommend this journal