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REVIEW ARTICLE
Year : 2011  |  Volume : 6  |  Issue : 6  |  Page : 87-94

Diagnosis of osteoarticular tuberculosis


1 Associate Professor, Department of Internal Medicine, Armed Forces Medical College, Pune, Maharashtra, India
2 Assistant Professor, Department of Internal Medicine, Armed Forces Medical College, Pune, Maharashtra, India

Correspondence Address:
Uday Yanamandra
Assistant Professor, Department of Internal Medicine, Armed Forces Medical College, Pune, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


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Accurate diagnosis in osteoarticular tuberculosis poses a difficulty due to deep inaccessible lesions, paucibacillary state, and initiation of empirical ATT in most of the cases. Diagnosis of osteoarticular TB evolved from clinicoradio- logical to serodiagnosis to detection of DNA/RNA of MTB origin. Newer modalities which aid in early diagnosis and treatment go a long way in management of osteoarticular TB by significantly decreasing morbidity. Subjecting all cases to panel of investigations including AFB staining, AFB culture/sensitivity, PCR, and histopathology on obtain- ing tissue have been proved more efficacious than resorting to single test. In particular serology alone is not diag- nostic. High sensitivity and specificity of PCR and histopathology are found to be most useful diagnostic modalities in studies. Thus gold standard remains to be tissue diagnosis.


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