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Year : 2012  |  Volume : 7  |  Issue : 5  |  Page : 80-86

Juvenile dermatomyositis: A review of clinical features and management

1 Department of Rheumatology, Nizam's Institute of Medical Sciences, Hyderabad, India
2 Department of Paediatric Rheumatology, Bristol Royal Hospital for Children and Royal National Hospital for Rheumatic Diseases, UK

Correspondence Address:
S Habibi
Department of Rheumatology, Nizam's Institute of Medical Sciences, Hyderabad, India

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Source of Support: None, Conflict of Interest: None

DOI: 10.1016/S0973-3698(12)60032-6

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Juvenile dermatomyositis is the most common of the idiopathic inflammatory myositis of childhood. It is characterised by a pathognomic skin rash along with proximal muscle weakness. It may also affect organs other than the muscle and skin. Calcinosis and lipodystrophy are complications of long-standing untreated or poorly treated disease, asso- ciated with chronic morbidity. A variety of environmental and genetic risk factors are implicated in its pathogenesis. Up-regulation of genes by type-I interferon appears central. Corticosteroids along with methotrexate are the mainstay of therapy. Disease outcome is in general good.

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