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REVIEW ARTICLE
Year : 2012  |  Volume : 7  |  Issue : 5  |  Page : 87-91

Kawasaki disease-A preventable cause of cardiac morbidity


Department of Paedaitrics, 2Professor of Paediatrics, The Paediatric Allergy Immunology Unit, Advanced Paediatrics Centre, PGIMER, Chandigarh, India

Correspondence Address:
Surjit Singh
Department of Paedaitrics, 2Professor of Paediatrics, The Paediatric Allergy Immunology Unit, Advanced Paediatrics Centre, PGIMER, Chandigarh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.1016/S0973-3698(12)60033-8

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Kawasaki disease is a common acute childhood vasculitis that can leave behind serious coronary sequelae. Though, it continues to be commonest in Japan, from where it was first described, it has been now described from all over the world. No specific aetiologic agent is known. Similarly, no single clinical feature or laboratory investigation is diagnostic. Intravenous immunoglobulin is the gold standard of care and if given within 10 days of onset, is associ- ated with a significantly reduced risk of coronary aneurysms. Despite appropriate care, 3% children still develop coronary artery abnormalities and require long-term aspirin therapy with or without anticoagulants. All children should be on long-term cardiac care because of risk of premature atherosclerosis and dyslipidaemia.


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