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ORIGINAL ARTICLE
Year : 2015  |  Volume : 10  |  Issue : 3  |  Page : 129-132

A comparison of clinical and laboratory profile of non-radiographic axial spondyloarthritis and ankylosing spondylitis


Department of Rheumatology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, PIN-500082, Telangana, India

Correspondence Address:
Liza Rajasekhar
Department of Rheumatology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, PIN-500082, Telangana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.injr.2015.05.008

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Objectives: To investigate the differences in clinical presentation, disease activity, HLA-B27 positivity in nr-axSpA and AS. Methods: Prospective observational study conducted in tertiary care centre from India. Total 125 consecutive patients with chronic low backache were screened,96 fulfilling ASAS criteria for axial SpA were included and grouped into radiographic (AS) (n = 55) and non- radiographic (n = 41) axial SpA. Demographic, clinical, disease activity and functional indices, ESR were noted from study group. HLA B27 testing was performed in study group by using an in-house PCR method. Results: Patients with AS compared with nr-axSpA were older at presentation (mean 33.7 ± 11.9 vs 26.5 ± 9, p < 0.001), longer mean time to disease diagnosis (4.4 ± 4 vs 1.3 ± 1.7,p < 0.0001) and had higher proportion of positive family history of SpA(29% vs 9.7%,p = 0.02). No statistical significant differences were found in male to female ratio, peripheral arthritis, dactylitis, enthesitis, ESR, HLA B27 positivity, disease activity and functional indices (BASDAI,BAS-G&BASFI) Conclusion: Though the clinical features and HLA B27 frequency is similar in nr-axSpA and AS, Patients with AS were older and had longer disease duration.


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