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ORIGINAL ARTICLE
Year : 2015  |  Volume : 10  |  Issue : 4  |  Page : 196-201

IL -17 is a key cytokine correlating with disease activity and clinical presentation of systemic lupus erythematosus IL-17 is a key cytokine correlating with disease activity and clinical presentation of systemic lupus erythematosus


1 Rheumatology & Rehabilitation Department, Faculty of Medicine, Zagazig University, Egypt; Medicine Department, Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia
2 Rheumatology & Rehabilitation Department, Faculty of Medicine, Zagazig University, Egyp
3 Laboratory Medicine Department, Faculty of Applied Medical Science, Umm Al-Qura University, Makkah 21955, Saudi Arabia

Correspondence Address:
Sahar M Abdel Galil
Rheumatology & Rehabilitation Department, Faculty of Medicine, Zagazig University, Egypt; Medicine Department, Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia

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Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.injr.2015.06.003

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Aims: To determine the role of IL-17 cytokine in systemic lupus erythematosus (SLE) patients and its association with clinical presentation of the disease and disease activity. Methods: 72 SLE patients and 70 healthy age and sex matched controls were included in the study. SLE disease activity was assessed in all patients with SLE disease activity index (SLEDAI-2K) scores. Plasma levels of IL-6, and IL-17 were measured by enzyme-linked immunosorbent assay and correlated their levels with clinical manifestations of the disease and SLEDAI-2K. Results: Plasma levels of IL-6 and IL-17 were significantly elevated in SLE patients than in control subjects (13.98 ± 6.95 versus 7.47 ± 1.23 pg/mL) and (19.47 ± 10.21 versus 9.93 ± 1.89 pg/mL), respectively. IL-6 and IL-17 were positively correlated with SLEDAI-2K scores (r = 0.684 at P < 0.001, r = 0.322 at P = 0.006), and lupus nephritis (r = 0.364 at P = 0.002, r = 0.474 at P < 0.001) respectively; similarly, the IL-17/IL-6 ratio was positively correlated with SLEDAI-2K (r = 0.243 at P = 0.039). Also, the level of both cytokines was positively correlated to each other during periods of disease activity (r = 0.755, P < 0.001) as well as during remission (r = 0.384, P = 0.040). Conclusion: Over-expression of IL-17 correlates with disease activity of SLE. A longitudinal study in a larger cohort of SLE patients can help validate the results.


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