Tab Application Banner
  • Users Online: 245
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2016  |  Volume : 11  |  Issue : 2  |  Page : 78-81

STAT4 rs7574865 polymorphism in Iranian patients with rheumatoid arthritis

1 Rheumatology Research Center, Tehran University of Medical Sciences; Department of Cell and Molecular Biology, University of Tehran, Tehran, Iran
2 Department of Cell and Molecular Biology, University of Tehran, Tehran, Iran
3 Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Correspondence Address:
Mahdi Mahmoudi
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.1016/j.injr.2016.02.002

Rights and Permissions

Objectives: The gene encoding signal transducer and activator of transcription 4 (STAT4) has been documented to be associated with rheumatoid arthritis (RA) in several populations. The aim of this study was to determine the association of the STAT4 gene polymorphism (rs7574865) with RA in the Iranian population. Methods: This study included 612 Iranian RA patients and 389 healthy control subjects. For all samples, DNA was genotyped for STAT4 G>T (rs7574865) polymorphism using the MGB TaqMan Allelic Discrimination method. Results: In our survey, the frequencies of GG, GT, and TT genotypes were 50%, 41.3%, and 8.7% in RA patients, and 51.4%, 37.5%, and 11.1% in controls (P > 0.05), respectively. STAT4 rs7574865 alleles were not associated with the disease risk in the Iranian population (P > 0.05). Conclusions: Although most studies have proposed STAT4 polymorphisms as a susceptible risk factor for RA, we did not detect any significant association between the STAT4 polymorphism and RA in our study. Population-based studies help to identify genetic determinants of disease susceptibility. Possible explanations for differences in susceptible genetic factors among populations could be different genetic predispositions and contribu- tion of gene-gene or gene-environment interactions.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded449    
    Comments [Add]    

Recommend this journal