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Year : 2016  |  Volume : 11  |  Issue : 4  |  Page : 202-206

Study on demography and outcome of extraglandular manifestations of primary sjögren's syndrome

1 Institute of Rheumatology, Madras Medical College; Saveetha Medical College Hospital, Thandalam, Chennai, India
2 Institute of Rheumatology, Madras Medical College, Chennai, India
3 Department of Community Medicine, Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research, Melmaruvathur, Chennai, India

Correspondence Address:
Dr. Kavitha Mohanasundaram
6 First Street, Shanthi Nagar, Adambakkam, Chennai - 600 088, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-3698.192690

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Background: Primary Sjögren's syndrome (pSS) is a systemic disease with a wide array of life-threatening extraglandular manifestations. The main objective of this study was to assess glandular and extraglandular manifestations of pSS. Methods: Eighty-two newly diagnosed pSS patients fulfilling revised American-European Consensus Group criteria of 2002 were included in the study. Twenty patients had predominantly glandular manifestations and 62 had predominant extra-glandular manifestations. Patients underwent baseline hematological, biochemical, immunological investigations, and imaging as needed. All patients underwent Schirmer's Test and lip biopsy irrespective of whether they had sicca symptoms or not. Results: The extraglandular manifestations observed in our patient were arthritis, neurological, renal, respiratory, and vasculitis. Almost 50% of patients with extraglandular manifestations did not have sicca symptoms. Cervical dental caries was seen in 40% of our patients with extraglandular manifestations. Our study had a higher percentage of renal involvement. Age at presentation and duration of illness were lower in the extraglandular group, which were statistically significant. European Sjögren's syndrome disease activity index (ESSDAI) at onset and at 1 year was higher in extraglandular group. Conclusion: The demography of patients with extraglandular manifestations in terms of age, duration of illness, and disease activity is different from those with only glandular manifestations.

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