Tab Application Banner
  • Users Online: 400
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 

 Table of Contents  
Year : 2016  |  Volume : 11  |  Issue : 4  |  Page : 239

Author's response

1 Division of Rheumatology, Department and Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
2 Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Campus, London NW3 2QG, UK

Date of Web Publication8-Nov-2016

Correspondence Address:
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-3698.193591

Rights and Permissions

How to cite this article:
Raja J, Denton CP. Author's response. Indian J Rheumatol 2016;11:239

How to cite this URL:
Raja J, Denton CP. Author's response. Indian J Rheumatol [serial online] 2016 [cited 2021 Apr 14];11:239. Available from:

Dear sir,

Delighted that the authors have interest in our article and welcome the additional information that is provided in their letter. Space limitation prevented all possible treatment approaches being discussed in detail and the comments about potential benefits of PDE5i are certainly relevant. These are also aligned with the major clinical trial that is underway at present examining possible anti-fibrotic benefit of a soluble guanylate cyclase agonists (riociguat) in systemic sclerosis skin disease (“” Identifier: NCT02283762). However fibrosis in systemic sclerosis and other conditions is complex and more studies are needed to understand this potential better. For example, there are also some potential concerns from studies of idiopathic lung fibrosis where vasodilator therapies may be disadvantageous in some cases. In line with recent expert recommendations, the widespread use of PDE5 inhibitors for digital vasculopathy and pulmonary arterial hypertension in SSc will hopefully help to answer some of these outstanding questions.


Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

  In this article

 Article Access Statistics
    PDF Downloaded51    
    Comments [Add]    

Recommend this journal