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Antineutrophil cytoplasmic antibody-associated vasculitis in a patient with diffuse scleroderma

1 Departmrnt of Rheumatology, Apollo BGS Hospital, Mysore, Karnataka, India
2 Departmrnt of Internal Medicine, Apollo BGS Hospital, Mysore, Karnataka, India

Correspondence Address:
BN Shiva Prasad,
Apollo BGS Hospital, Mysore, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/injr.injr_84_20

Scleroderma is a multiorgan connective tissue disease characterized by autoantibody production and fibroproliferative stenosis of the microvasculature. The development of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis in patients with scleroderma is a rare association. Renal and pulmonary complications occur more frequently than expected in scleroderma/ANCA-associated vasculitis overlap. The definitive diagnosis usually made based on autoantibody titers and biopsy of involved tissue. We present a case of diffuse scleroderma with ANCA-associated vasculitis presenting with neurological symptoms.

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