Indian Journal of Rheumatology

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 6  |  Issue : 4  |  Page : 168--172

Role of vascular endothelial growth factor and monocyte chemoattractant protein-1 in Behηet俟Q製 disease


Soha ElDessouki Ibrahim1, Heba Fawzi Elshishtawy2, Amir HelmySamy3, Zeinab Ali Galal4 
1 Lecturer, Department of Rheumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2 Assistant Professor, Department of Rheumatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
3 Lecturer, Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
4 Lecturer, Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

Correspondence Address:
Soha ElDessouki Ibrahim
Lecturer, Department of Rheumatology, Faculty of Medicine, Ain Shams University, Cairo
Egypt

Objectives: To study the role of vascular endothelial growth factor (VEGF) and monocyte chemoattractant protein-1 (MCP-1) in Behηet俟Q製 disease and their relation to clinical manifestations particularly vascular manifestations and disease activity. Methods: Forty Behηet俟Q製 disease patients (32 males, 8 females), diagnosed according to the criteria proposed by the International Study Group for Behηet俟Q製 disease were assessed clinically and serum VEGF and MCP-1 were measured by enzyme-linked immunosorbent assay. Results: Serum VEGF and MCP-1 levels were detected in patients and control groups with highly significant increase in Behηet俟Q製 group. A highly significant increase in the level of serum VEGF and MCP-1 was found in patients with vascular manifestations compared to those without vascular complications. A significant increase in the level of VEGF and MCP-1 was found in patients with active disease compared to inactive. Conclusion: Our findings suggest that serum VEGF and MCP-1 levels are elevated in active Behηet俟Q製 patients and in patients with vascular complications. So, we conclude that VEGF and MCP-1 play a crucial role in the pathogen- esis of vascular complications of Behηet俟Q製 disease. Therefore, the serum levels of these cytokines serve to predict a possible acute thrombosis in Behηet俟Q製 disease.


How to cite this article:
Ibrahim SE, Elshishtawy HF, HelmySamy A, Galal ZA. Role of vascular endothelial growth factor and monocyte chemoattractant protein-1 in Behηet's disease .Indian J Rheumatol 2011;6:168-172


How to cite this URL:
Ibrahim SE, Elshishtawy HF, HelmySamy A, Galal ZA. Role of vascular endothelial growth factor and monocyte chemoattractant protein-1 in Behηet's disease . Indian J Rheumatol [serial online] 2011 [cited 2021 Nov 30 ];6:168-172
Available from: https://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2011;volume=6;issue=4;spage=168;epage=172;aulast=Ibrahim;type=0