Indian Journal of Rheumatology

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 6  |  Issue : 4  |  Page : 178--184

Study of endothelial dysfunction and its correlation with disease activity in systemic lupus erythematosus patients without conventional cardiovascular risk factors


Apurba Bikash Pramanik1, Kuntal Bhattacharyya2, Pradip Kumar Sinha3, Rathindra Nath Sarkar4, Rudrajit Paul1, Runa Das5, Siddhartha Mani1, Raja Bhattacharya1 
1 Senior Resident, Department of Medicine, Calcutta Medical College, Kolkata, India
2 Junior Resident, Department of Medicine, Calcutta Medical College, Kolkata, India
3 Associate Professor, Department of Medicine, Calcutta Medical College, Kolkata, India
4 Professor, Department of Medicine; Head, Rheumatology Division, Calcutta Medical College, Kolkata, India
5 Assistant Professor, Department of Radiology, Calcutta Medical College, Kolkata, India

Correspondence Address:
Rathindra Nath Sarkar
Professor, Department of Medicine; Head, Rheumatology Division, Calcutta Medical College, Kolkata
India

Background: Endothelial dysfunction is an important cause of cardiovascular morbidity and mortality in patients of systemic lupus erythematosus (SLE), causing atherosclerosis and its related complications, even in the absence of conventional cardiovascular risk factors. Objective: The present study was aimed at finding the prevalence of endothelial dysfunction in SLE and its relation with disease activity. Methods: Fifty SLE patients without traditional cardiovascular risk factors, and equal number of age and sex matched controls were chosen. Endothelial function was assessed by flow mediated vasodilatation (FMV) on brachial artery, using B-mode ultrasonography. Results: Mean age of SLE patients was 26.06 ± 6.231 years. Thirty-seven (74%) of the patients were having severe disease activity, defined as systemic lupus erythematosus disease activity index (SLEDAI) > 8. We found signifi- cantly lower levels of basal brachial artery diameter in SLE patients (0.3499 ± 0.075 cm) compared to controls (0.3826 ± 0.0002 cm), as also impaired FMV (2.57 ± 2.32% and 8.7082 ± 1.5776%, respectively). Flow mediated vasodilatation significantly correlated with SLEDAI (r = −0.52) and complement (C3) levels (r = 0.33). Conclusion: Endothelial dysfunction in SLE correlates with disease activity.


How to cite this article:
Pramanik AB, Bhattacharyya K, Sinha PK, Sarkar RN, Paul R, Das R, Mani S, Bhattacharya R. Study of endothelial dysfunction and its correlation with disease activity in systemic lupus erythematosus patients without conventional cardiovascular risk factors.Indian J Rheumatol 2011;6:178-184


How to cite this URL:
Pramanik AB, Bhattacharyya K, Sinha PK, Sarkar RN, Paul R, Das R, Mani S, Bhattacharya R. Study of endothelial dysfunction and its correlation with disease activity in systemic lupus erythematosus patients without conventional cardiovascular risk factors. Indian J Rheumatol [serial online] 2011 [cited 2021 Mar 7 ];6:178-184
Available from: https://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2011;volume=6;issue=4;spage=178;epage=184;aulast=Pramanik;type=0