Indian Journal of Rheumatology

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 10  |  Issue : 1  |  Page : 2--9

Analysis of evidence to determine the link between Takayasu俟Q製 arteritis and Tuberculosis


Arun R Chogle1, Darshil A Shah2, Clancy Cerejo2 
1 Department of Rheumatology, Saifee Hospital and Medical Research Center, Charni Road, Mumbai 400 004, India
2 Department of Medicine, Saifee Hospital and Medical Research Center, Charni Road, Mumbai 400 004, India

Correspondence Address:
Arun R Chogle
Department of Rheumatology, Saifee Hospital and Medical Research Center, Charni Road, Mumbai 400 004
India

Objective: The relationship of Takayasu俟Q製 arteritis (TA) and Tuberculosis (TB) has been suggested for decades but convincing evidence is lacking. The aim of this study is to assess the published evidence for an association between TA and TB. Method: We performed a systematic search of the MEDLINE database through PubMed using MeSH headings and keywords for 非Q蓉akayasu俟Q製 arteritis非Q and 非Q蓉uberculosis非Q. Results: Thirty seven publications were analysed. The sites of TB lesions in these TA cases were mainly found in lymph nodes and lungs and occasionally in the internal organs and skin. One histopathological study did not support the direct role of mycobacterium TB in the pathogenesis of arterial lesions while the other suggested that the arterial damage could occur due to previous TB infection. Regional differences in the prevalence of TB may have influenced the validity of the results. The laboratory studies support the idea of molecular mimicry between mycobacterium heat shock protein (mHSP65) and its human homologue (hHSP60) driving immune response in TA. Based on the epidemiological, immunological and genetic factors, three hypotheses have been proposed to explain the TA and TB link. Conclusions: The mycobacterium theory can neither be confirmed nor excluded with cer- tainty. The proposed hypotheses require future confirmatory studies. Randomised controlled trials are needed to ascertain safety of biologics in TA cases with associated TB infection.


How to cite this article:
Chogle AR, Shah DA, Cerejo C. Analysis of evidence to determine the link between Takayasu's arteritis and Tuberculosis.Indian J Rheumatol 2015;10:2-9


How to cite this URL:
Chogle AR, Shah DA, Cerejo C. Analysis of evidence to determine the link between Takayasu's arteritis and Tuberculosis. Indian J Rheumatol [serial online] 2015 [cited 2021 Oct 16 ];10:2-9
Available from: https://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2015;volume=10;issue=1;spage=2;epage=9;aulast=Chogle;type=0