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  Citation statistics : Table of Contents
   2015| March  | Volume 10 | Issue 1  
    Online since August 1, 2016

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Relationship between bone mineral density and duration of rheumatoid arthritis
Behzad Heidari, Alireza Firouzjahi, Maryam Haj Mirghssemi, Parham Heidari, Niloofar Hakimi, Karim Hajian-Tilaki
March 2015, 10(1):10-15
Background: Longer disease duration is believed to be associated with more pronounced bone loss in rheumatoid arthritis (RA). This study was designed to assess bone mineral density (BMD) status in RA compared with age-matched control in relation to disease duration. Methods: This study included 177 RA and 283 age-matched non-RA controls. BMD at the femoral neck and lumbar spine was assessed by Dual Energy X-ray Absorptiometry Oste- oporosis was diagnosed according to WHO criteria. We divided patients with RA into groups based on disease duration of <2, 2-5, 5e10, and >10 years and compared them with controls. The relationship between disease duration and BMD was investigated by chi square and Spearman test. Results: Mean age of patients and control subjects was 51.2 ± 12.5 and 52.2 ± 6.7 years, respectively and mean disease duration was 86.5 ± 73.3 months. Osteoporosis at the femoral neck and lumbar spine in patients with RA was significantly higher than in con- trols. Femoral neck BMD in RA was negatively correlated with disease duration and 4.5% variations of femoral neck BMD was explained by disease duration (r2 Ό 0.045, P Ό 0.005). Odds Ratio (OR) for osteoporosis in RA patients as compared to controls was increased by prolongation of disease duration from 2.38 (0.38-14.7) in patients with disease duration <2 years to 12.56 (2.24e70.2) in patients with disease duration >10 years. For patients treated with methotrexate compared to those who had never received methotrexate the odds ratio for femoral neck osteoporosis reduced by 64% (OR Ό 0.36, 95% CI, 0.15-0.91). Conclusion: There is a significant negative relationship between femoral neck BMD and disease duration in RA. The value of OR increases proportionately with lengthening of disease duration which can be reduced significantly by methotrexate therapy.
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Analysis of evidence to determine the link between Takayasu's arteritis and Tuberculosis
Arun R Chogle, Darshil A Shah, Clancy Cerejo
March 2015, 10(1):2-9
Objective: The relationship of Takayasu's arteritis (TA) and Tuberculosis (TB) has been suggested for decades but convincing evidence is lacking. The aim of this study is to assess the published evidence for an association between TA and TB. Method: We performed a systematic search of the MEDLINE database through PubMed using MeSH headings and keywords for "Takayasu's arteritis" and "Tuberculosis". Results: Thirty seven publications were analysed. The sites of TB lesions in these TA cases were mainly found in lymph nodes and lungs and occasionally in the internal organs and skin. One histopathological study did not support the direct role of mycobacterium TB in the pathogenesis of arterial lesions while the other suggested that the arterial damage could occur due to previous TB infection. Regional differences in the prevalence of TB may have influenced the validity of the results. The laboratory studies support the idea of molecular mimicry between mycobacterium heat shock protein (mHSP65) and its human homologue (hHSP60) driving immune response in TA. Based on the epidemiological, immunological and genetic factors, three hypotheses have been proposed to explain the TA and TB link. Conclusions: The mycobacterium theory can neither be confirmed nor excluded with cer- tainty. The proposed hypotheses require future confirmatory studies. Randomised controlled trials are needed to ascertain safety of biologics in TA cases with associated TB infection.
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  1 1,342 111
Dr. Hulusi Behcet
VR Joshi, VB Poojary
March 2015, 10(1):36-36
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  - 984 60
Indian Journal of Rheumatology: The highs and lows of 2014
Amita Aggarwal
March 2015, 10(1):1-1
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  - 1,077 222
An unusual cause of shoulder pain
Kaouther Ben Abdelghani, Maroua Slouma, Selma Chekili, Ahmed Laatar, Leith Zakraoui
March 2015, 10(1):31-32
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  - 1,086 83
Ichthyosiform sarcoidosis in an Indian child
Rachel Ranitha Peterson, Jacob Mathew Vahaneyil, Bhavya Onkarappa, Suni Augustine, Priya Chandrasekharan
March 2015, 10(1):33-34
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  - 1,010 189
Arthrodesis-like effect of tumor necrosis factor inhibitor in a patient with rheumatoid arthritis
Masao Sato, Masao Takemura
March 2015, 10(1):35-36
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  - 1,029 197
Pyoderma gangrenosum in lupus
Kavitha Mohanasundaram, Sankaran Sriram, Mani Madeshwaran, Selvakumar Balameena, Sankaralingam Rajeswari
March 2015, 10(1):37-38
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  - 1,046 89
Radiological resolution of peri-aortic thickening in a patient with IgG4 disease
Taral Parikh, Canchi Balakrishnan, GC Yathish, Piyush Joshi, Bhargav Doshi, Gurmeet Mangat, Rohini Samant, Vinay Joshi
March 2015, 10(1):39-40
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  - 1,061 76
Rheumatology reviews
Sukhbir Uppal
March 2015, 10(1):41-47
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  - 997 171
T-lymphoblastic lymphoma in an undiagnosed rheumatoid arthritis patient - a rare occurrence
HS Darling, S Viswanath, V Rajeev
March 2015, 10(1):48-50
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  - 981 203
International publications of interest from India (September-November 2014)
Vivek Arya
March 2015, 10(1):20-23
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  - 1,073 200
From confusion to consensus: Need for multi disciplinary team approach in rheumatology: An orthopaedic surgeons's perpective
Bhushan Kumar Chopra, Ashutosh Chauhan
March 2015, 10(1):16-18
Aim of joint surgeries in rheumatoid arthritis is to restore function and quality of life, prevent joint deterioration, relieve pain and correct deformity in patients afflicted with rheumatoid disorders With advent of newer therapeutic modalities, the need for joint surgeries in cases of rheumatoid disorders has drastically reduced over the past two decades. Decision-making and timing for orthopaedic intervention are complex issues because of polyarticular involvement in rheumatoid disorder. Optimal results from the surgery demands close team work between the rheumatologists and the orthopaedic surgeon. However, as studies, have indicated, there appears to be divergent views amongst rheumatologist and the orthopaedic surgeon as regards indications, timing and effectiveness of rheumatoid joint surgery. This is to the detriment of the patient's best interest. Therefore, it is imperative that a multidisci- plinary team approach be adopted towards managing each patient. The need of the hour is evolution of integrated Rheumatology Team comprising of rheumatologist, orthopaedic surgeon, pain care specialist, physiotherapist and nurse, a close synergy of interests to provide holistic care to patients of inflammatory joint disorders.
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  - 1,298 95
Rheumatology quiz
Vivek Arya, Varun Dhir
March 2015, 10(1):19-19
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  - 1,105 174
How to plan a good caseecontrol study?
Rakesh Aggarwal
March 2015, 10(1):24-30
Caseecontrol studies are a very frequently used restudy design in clinical and epidemio- logical research. They are popular because they are easy, quick and inexpensive to plan and conduct. Despite the risk of several types of biases (selection bias, recall and mea- surement bias, and confounding), their results are often fairly robust. This article explains the basic steps in the design and conduct of caseecontrol studies, and also explains their usual pitfalls, from the perspective of a clinical researcher.
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