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  Indian J Med Microbiol
 

Figure 2: HLA-B27 molecule is intrinsically unstable molecule which in the endoplasmic reticulum elicits unfolded protein response resulting in stimulation of IL-17 and IL-23 proinflammatory cytokines important in the pathogenesis of AS. ATF6: Activating transcription factor 6; ER: Endoplasmic reticulum; IRE1: Inositol-requiring enzyme 1; PERK: Protein kinase R-like endoplasmic reticulum kinase; HLA: Human leukocyte antigen; IL: Interleukin

Figure 2: HLA-B27 molecule is intrinsically unstable molecule which in the endoplasmic reticulum elicits unfolded protein response resulting in stimulation of IL-17 and IL-23 proinflammatory cytokines important in the pathogenesis of AS. ATF6: Activating transcription factor 6; ER: Endoplasmic reticulum; IRE1: Inositol-requiring enzyme 1; PERK: Protein kinase R-like endoplasmic reticulum kinase; HLA: Human leukocyte antigen; IL: Interleukin