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  Indian J Med Microbiol
 

Figure 3: HLA-B27 has property to form homodimers that are dependent on residue Cys67 in their extracellular α1 domain. Cell surface B272 (homodimer) binds to innate immune receptors such as killer immunoglobulin receptors KIR3DL1, KIR3DL2, and leukocyte immunoglobulin-like receptor LILIRB2 on CD4 + T-cells, NK cells, and myeloid cells in humans. The KIR3DL2/B27 interaction has pro-inflammatory effects on both NK and T-cells and favors a Th17 phenotype in ankylosing spondylitis. CD: Cluster of differentiation; NK: Natural killer

Figure 3: HLA-B27 has property to form homodimers that are dependent on residue Cys67 in their extracellular α1 domain. Cell surface B27<sub>2</sub> (homodimer) binds to innate immune receptors such as killer immunoglobulin receptors KIR3DL1, KIR3DL2, and leukocyte immunoglobulin-like receptor LILIRB2 on CD4<sup> </sup>+ T-cells, NK cells, and myeloid cells in humans. The KIR3DL2/B27 interaction has pro-inflammatory effects on both NK and T-cells and favors a Th17 phenotype in ankylosing spondylitis. CD: Cluster of differentiation; NK: Natural killer